A double-masked, randomized clinical trial comparing latanoprost with unoprostone in patients with open-angle glaucoma or ocular hypertension☆
Received 25 February 2000; accepted 28 August 2000.
Abstract
Purpose
To compare the intraocular pressure (IOP) reducing effect and safety of latanoprost 0.005% once daily with unoprostone 0.12% twice daily in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OH).
Design
An 8-week, double-masked, randomized, parallel-group, single-center clinical trial.
Participants
A total of 108 patients with POAG or OH were enrolled.
Interventions
After completing a wash-out of ocular hypotensive medications, patients were randomized to receive either latanoprost once daily in the evening plus placebo once daily in the morning, or unoprostone twice daily (morning and evening).
Main outcome measures
IOP was measured at 10:00 AM and at 5:00 PM at baseline and at week 8, and before 12:00 noon at week 2. Ocular and systemic safety assessments were performed.
Results
From an overall baseline of 24.1 mmHg, latanoprost reduced IOP by 6.7 mmHg (28%) and unoprostone reduced IOP by 3.3 mmHg (14%). The difference between the groups of 3.4 mmHg was significant (P < 0.001, analysis of covariance; 95% confidence interval [CI]: −4.7 to −2.1) in favor of latanoprost. A ≥30% reduction in mean IOP from baseline was achieved by 44% of latanoprost-treated patients compared with 8% of unoprostone-treated patients. The incidence of adverse events was low and comparable between the groups.
Conclusions
Latanoprost administered once daily was significantly more effective in reducing IOP compared with unoprostone administered twice daily in patients with POAG and OH.
Manuscript no. 200109.
aGlaucoma Service, Department of Ophthalmology and Otolaringology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil
Reprint requests to: Remo Susanna, Jr., MD, Glaucoma Service, Department of Ophthalmology and Otolaringology, University of São Paulo, São Paulo, Brazil
☆ Supported by Pharmacia & Upjohn, Uppsala, Sweden.
ABSTRACT