Optic Disc Hemorrhage May Be Associated with Retinal Nerve Fiber Loss in Otherwise Normal Eyes
Received 11 March 2008; received in revised form 7 July 2008; accepted 8 August 2008.
Purpose
To evaluate quantitatively the structural damage of the peripapillary retinal nerve fiber layer (RNFL) in eyes with disc hemorrhage (DH).
Design
Prospective cross-sectional study.
Participants
Seventy patients with DH (70 eyes; mean age ± standard deviation, 60.0±11.8 years) and 100 healthy control subjects (100 eyes; mean age ± standard deviation, 57.7±8.0 years) were enrolled from the Glaucoma Clinic of Seoul National University Hospital.
Methods
Normal eyes without DH (group 1: normal control group) served as controls. Eyes with DH were divided into the following groups: (1) eyes with a DH, accompanied by no visible RNFL defect according to red-free fundus photography and normal visual fields (group 2: DH only group); (2) eyes with a DH and a localized RNFL defect in the same quadrant, accompanied by normal visual fields (group 3: DH-preperimetric group); and (3) eyes with a DH and a localized RNFL defect in the same quadrant, accompanied by glaucomatous visual field defect in the corresponding hemifield location (group 4: DH-perimetric group). Optical coherence tomography (OCT)-measured RNFL thicknesses were compared.
Main Outcome Measures
Average and segmental (4 quadrants and 12 clock-hours) OCT-measured RNFL thicknesses.
Results
The number of eyes in groups 1, 2, 3, and 4 was 100, 25, 22, and 23 eyes, respectively. The OCT-measured RNFL thickness was significantly different among the 4 groups in average RNFL thickness and in inferior, superior, and nasal quadrants (P<0.01, 1-way analysis of variance). On post hoc analysis, the eyes of groups 2 and 3 showed thinner average RNFL thickness than those of group 1, and the average RNFL thickness of group 4 was significantly lower than that of groups 2 and 3 (P<0.001, 1-way analysis of variance and Tukey's test). The OCT-measured RNFL thickness revealed a topographic relationship with the DH location.
Conclusions
Significant RNFL loss was already present in the DH only eyes with apparently normal RNFL configuration by red-free fundus photography, indicating that preperimetric changes of the RNFL are already present. These results suggest that OCT has the potential to detect subclinical or preperimetric RNFL loss in the eyes with DH.
Financial Disclosure(s)
The authors have no proprietary or commercial interest in any of the materials discussed in this article.
1Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea
2Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
3Department of Ophthalmology, East-west Neo Medical Center, Seoul, Korea
4Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Korea
Correspondence: Ki Ho Park, MD, Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, #28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea
Manuscript no. 2008-325.
Financial Disclosure(s): The authors have no proprietary or financial interest in any of the products or techniques described in the article.
ABSTRACT