How to predict proliferative vitreoretinopathy: A prospective study1☆
Received 9 November 1999; accepted 2 January 2001.
Abstract
Purpose
To determine prospectively the accuracy of a predictive risk formula for the development of postoperative proliferative vitreoretinopathy (PVR) when applied in a clinical setting.
Design
Prospective noncomparative interventional case series.
Participants
Two hundred nineteen subjects undergoing primary vitrectomy for rhegmatogenous retinal detachment were studied.
Method
By use of a formula-based discriminant rule, subjects were classified as either high or low risk for the development of PVR. All subjects were followed prospectively.
Outcome measures
Development of postoperative PVR as defined by the updated the Retina Society Classification.
Results
Complete data were available on 212 of 219 subjects. There were 130 subjects identified as low risk and 82 subjects as high risk; 9.2% of the low-risk (12 of 130) compared with 28% (23 of 82) of the high-risk subjects had postoperative PVR develop. This difference was statistically significant (P < 0.001).
Conclusions
Our study has shown that using a clinical model it is possible to identify subjects at greater risk of PVR developing after primary vitrectomy.
Manuscript no. 99740.
1Departments of Vitreoretinal Surgery and Glaucoma, Moorfields Eye Hospital, London, England, UK
2Wound Healing Research Unit, Department of Pathology, Institute of Ophthalmology, London, England, UK
3Medical Statistician, Moorfields Eye Hospital, London, UK, England
4Vitreoretinal Department, The Royal Liverpool University Hospitals, Liverpool, England, UK,
Reprint requests to Dr. R.H.Y Asaria, Moorfields Eye Hospital, Department of Vitreoretinal Surgery, City Road, London, EC1V 9EL, England
☆ Supported by June Sutor Fellowship, London, England; Guide Dogs for the Blind Association, London, England; The National Health Service (NHS) London, England; Research and Development Support Funding London, England; PTK is supported by Medical Research Council grant 9330070.
1 This work was undertaken by the authors who Received funding from the NHS Executive; the views expressed in this publication are those of the authors and not necessarily of the NHS Executive.
ABSTRACT