Positron Emission Tomography in the Detection and Staging of Ocular Adnexal Lymphoproliferative Disease
Received 30 September 2005; accepted 1 May 2006. published online 21 September 2006.
Purpose
To evaluate the role of fluorine 18 deoxyglucose positron emission tomography (FDG PET) in the initial staging of ocular adnexal lymphoma (OAL).
Design
Retrospective nonrandomized case series.
Participants
Eleven patients with OAL who underwent FDG PET at initial staging.
Methods
Retrospective review of all the clinical and imaging records, including computed tomography (CT) and FDG PET.
Main Outcome Measures
The ability of PET studies to detect OAL and distant disease was compared with CT.
Results
Eleven patients with OAL who underwent FDG PET at initial staging were retrospectively reviewed having full access to their clinical and imaging data. Fluorine 18 deoxyglucose PET found distant disease in 5 of 6 lymphoma patients with systemic disease; 4 of these patients (66%) were upstaged, changing the clinical management. Orbital lesions were demonstrated in 3 of 11 patients, giving PET a sensitivity of 27% in the orbit and 83% systemically for detection of lymphoma.
Conclusion
The ability of FDG PET to find systemic extranodal lymphomatous sites not detected with conventional imaging provides valuable information in OAL patients, which may result in important changes in staging and management. The technique does have limitations in detecting OAL compared with conventional imaging, possibly owing to background physiologic activity in the extraocular muscles in the orbit and the small volume of some orbital deposits.
1Eyelid, Lacrimal and Orbital Clinic, Department of Ophthalmology, Division of Surgery, Royal Brisbane and Women’s Hospital and The University of Queensland Medical School, Herston, Australia.
2Wesley PET Centre, Wesley Hospital, Auchenflower, Australia.
3Brisbane Haematology Oncology Clinic, Wesley Medical Centre, Auchenflower, Australia.
Correspondence to Timothy J. Sullivan, Eyelid, Lacrimal and Orbital Clinic, Department of Ophthalmology, Royal Brisbane Hospital, Herston, Queensland 4029, Australia.
Manuscript no. 2006-23.
The authors have no proprietary interests in any of the products mentioned in the article, and there is no financial support involved.
ABSTRACT