Ophthalmology
Volume 114, Issue 6 , Pages 1053-1057 , June 2007

Retinal Nerve Fiber Layer Damage as Assessed by Optical Coherence Tomography in Eyes with a Visual Field Defect Detectedby Frequency Doubling Technology Perimetry but Not by Standard Automated Perimetry

  • Tae-Woo Kim, MD

      Affiliations

    • Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
    • ,
  • Linda M. Zangwill, PhD

      Affiliations

    • Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla, California.
    • ,
  • Christopher Bowd, PhD

      Affiliations

    • Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla, California.
    • ,
  • Pamela A. Sample, PhD

      Affiliations

    • Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla, California.
    • ,
  • Neha Shah, MD

      Affiliations

    • Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla, California.
    • ,
  • Robert N. Weinreb, MD

      Affiliations

    • Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla, California.
    • Corresponding Author InformationCorrespondence to Robert N. Weinreb, MD, Hamilton Glaucoma Center, University of California San Diego, 9500 Gilman Drive, Department 0946, La Jolla, CA 92093-0946.

Received 21 March 2006 ,Accepted 13 September 2006.

References 

  1. Paczka JA, Friedman DS, Quigley HA, et al. Diagnostic capabilities of frequency-doubling technology, scanning laser polarimetry, and nerve fiber layer photographs to distinguish glaucomatous damage. Am J Ophthalmol. 2001;131:188–197
  2. Kondo Y, Yamamoto T, Sato Y, et al. A frequency-doubling perimetric study in normal-tension glaucoma with hemifield defect. J Glaucoma. 1998;7:261–265
  3. Wu LL, Suzuki Y, Kunimatsu S, et al. Frequency doubling technology and confocal scanning ophthalmoscopic optic disc analysis in open-angle glaucoma with hemifield defects. J Glaucoma. 2001;10:256–260
  4. Medeiros FA, Sample PA, Weinreb RN. Frequency doubling technology perimetry abnormalities as predictors of glaucomatous visual field loss. Am J Ophthalmol. 2004;137:863–871
  5. El Beltagi TA, Bowd C, Boden C, et al. Retinal nerve fiber layer thickness measured with optical coherence tomography is related to visual function in glaucomatous eyes. Ophthalmology. 2003;110:2185–2191
  6. Maddess T, Henry GH. Performance of nonlinear visual units in ocular hypertension and glaucoma. Clin Vis Sci. 1992;7:371–383
  7. Anderson AJ, Johnson CA. Mechanisms isolated by frequency-doubling technology perimetry. Invest Ophthalmol Vis Sci. 2002;43:398–401
  8. Johnson CA, Demirel S. The role of spatial and temporal factors in frequency-doubling perimetry. In:  Wall M,  Heijl A editor. Perimetry Update 1996/1997: Proceedings of the XIIth International Perimetric Society Meeting, Würzburg, Germany, June 4–8, 1996. Amsterdam: Kugler; 1997;p. 13–19
  9. Johnson CA. Selective versus nonselective losses in glaucoma. J Glaucoma. 1994;3(suppl):S32–S44
  10. Glovinsky Y, Quigley HA, Dunkelberger GR. Retinal ganglion cell loss is size dependent in experimental glaucoma. Invest Ophthalmol Vis Sci. 1991;32:484–491
  11. Quigley HA, Dunkelberger GR, Green WR. Chronic human glaucoma causing selectively greater loss of large optic nerve fibers. Ophthalmology. 1988;95:357–363
  12. Chaturvedi N, Hedley-Whyte ET, Dreyer EB. Lateral geniculate nucleus in glaucoma. Am J Ophthalmol. 1993;116:182–188
  13. Heijl A, Lundqvist L. The frequency distribution of earliest glaucomatous visual field defects documented by automatic perimetry. Acta Ophthalmol (Copenh). 1984;62:658–664

 Manuscript no. 2006-348.

 Disclosure: research support from Carl Zeiss Meditec (LMZ, PAS, RNW), Heidelberg Engineering (LMZ, RNW), Welch-Allyn (PAS), and Haag-Streit (PAS). Honoraria from Heidelberg Engineering (LMZ, RNW) and Carl Zeiss Meditec (RNW).

 Supported by the National Institutes of Health, Bethesda, Maryland (grant nos. EY11008 [LMZ], EY08208 [PAS]). Participant retention incentive grants in the form of glaucoma medication at no cost: Alcon Laboratories, Inc., Fort Worth, Texas; Allergan, Irvine, California; Pfizer, Inc., New York, New York; and Santen, Inc., Napa, California.

PII: S0161-6420(06)01313-3

doi: 10.1016/j.ophtha.2006.09.015

Ophthalmology
Volume 114, Issue 6 , Pages 1053-1057 , June 2007

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