Effect of Age on the Development of a Latanoprost-Induced Increase in Iris Pigmentation
Presented at: International Glaucoma Symposium, March 30–April 2, 2005, Cape Town, South Africa.
Received 12 March 2006; accepted 30 October 2006. published online 15 February 2007.
Purpose
To study the effect of patient age on the incidence of latanoprost-induced increases in iris pigmentation.
Design
Prospective observational observer-masked study.
Participants
Thirty-six patients younger than 60 years (group 1) and 36 patients older than 75 years (group 2) with primary open-angle glaucoma.
Methods
We photographed both irises of each patient before and 6 months after unilateral latanoprost therapy. The basal iris colors were matched in both groups.
Main Outcome Measures
Iris heterochromia identification at the 6-month evaluation of the photographs.
Results
Twenty-eight patients (77.78%) in group 2 developed an increase in iris pigmentation compared with eight patients (22.22%) in group 1 (P = 0.0001, chi-square test).
Conclusions
Age seems to be an important risk factor for latanoprost-induced iris color change.
ABSTRACT