Mortality in Patients with Branch Retinal Vein Occlusion
Received 18 September 2005; accepted 9 January 2007.
Purpose
To assess the impact of branch retinal vein occlusion (BRVO), a condition related to arteriolar wall thickening, as a prognostic marker of mortality.
Design
Long-term follow-up study comparing cases with background population.
Participants
Patients diagnosed with BRVO.
Methods
Diagnosis of BRVO confirmed by fundus photographic records including color diapositives and fluorescein angiograms.
Main Outcome Measures
Observed and expected numbers of deaths determined from comprehensive civic records in cases compared with the background population (5.4 million).
Results
Branch retinal vein occlusion was found in 329 patients (173 women, 156 men) born between 1902 and 1956, who were 39 to 91 years old when diagnosed between 1973 and 1998. Follow-up was concluded on July 8, 2004, when 144 deaths were recorded in patients (74 women, 70 men), compared with an expected number of 145.5 deaths in the background population (standardized mortality rate, 0.99; 95% confidence interval, 0.84–1.16). Stratified analyses revealed no significant effect of age, gender, or time of diagnosis.
Conclusions
In this study of 329 patients with BRVO, we found no significant difference in mortality between patients and the background population. An association between BRVO and cardiovascular/cerebrovascular risk factors has previously been documented in cross-sectional studies. The contrasting outcome in this longitudinal study may have been influenced by interventions instituted after the diagnosis of BRVO was made and by preferential survival before the diagnosis of BRVO of the more fit patients with the necessary precursor condition of having arteriovenous nicking, which is more prevalent in subjects with diabetes and hypertension.
1Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark.
3Department of Ophthalmology, Odense University Hospital, Odense, Denmark.
4Department of Ophthalmology, Aalborg Hospital, Aalborg, Denmark.
5National Institute of Public Health, Hellerup, Denmark.
Correspondence to Michael Larsen, Department of Ophthalmology, Glostrup Hospital, DK-2600 Glostrup, Denmark.
Manuscript no. 2005-884.
Supported by the Værn Om Synet, Copenhagen, Denmark, and Juvenile Diabetes Research Foundation, New York, New York (Patient-Oriented Diabetes Research Career Award, grant no. 8-2002-130 [ML]).
The authors have no relevant financial or proprietary interest in any aspect of the study.
ABSTRACT