Histopathologic and Trypsin Digestion Studies of the Retina in Incontinentia Pigmenti
Received 18 May 2007; received in revised form 23 July 2007; accepted 14 August 2007. published online 01 November 2007.
Objective
To report the ocular histopathologic features of a 55-year-old patient with incontinentia pigmenti retinopathy.
Design
Observational case report.
Participant
A 55-year-old patient with incontinentia pigmenti retinopathy.
Methods
Examination of eyes by light microscopy and retinal trypsin digestion.
Main Outcome Measures
Clinical and histopathological findings.
Results
Histopathologic examination disclosed inner retinal ischemic atrophy, capillary beading, arteriolar–venous anastomoses, preretinal neovascularization, vasculopathy located at the junction of central vascular and peripheral avascular retina, retinal tears, and tractional retinoschisis.
Conclusions
Patients with retinal manifestations of incontinentia pigmenti may progress to proliferative vitreoretinopathy or retinal detachment and should be observed closely over the course of their lifetime.
Available online: November 5, 2007.
1Eye Pathology Laboratory, Department of Pathology, Wilmer Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland.
2Retina Service, Wilmer Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Correspondence and reprint requests to Morton F. Goldberg, MD, Wilmer Eye Institute, Woods 276, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287-9128.
Manuscript no. 2007-665.
Supported in part by Independent Order of Odd Fellows, Winston-Salem, North Carolina (WRG), and the Guerrieri Retinal Research Fund at the Wilmer Eye Institute (MFG).
The authors have no financial or proprietary interests in the subject.
ABSTRACT