Carcinosarcoma of the Orbit: Report of Two Cases and Review of the Literature
Received 9 February 2008; received in revised form 27 March 2008; accepted 25 April 2008. published online 17 June 2008.
Objective
To report the clinicopathologic features of 2 patients with carcinosarcoma of the orbit.
Design
Case reports.
Participants
Two patients with orbital carcinosarcoma were identified.
Methods
Retrospective chart review with clinicopathologic correlation and literature review.
Main Outcome Measures
Clinical examination, imaging studies, and histopathologic findings.
Results
Two patients, a 56-year-old woman and a 91-year-old woman, with orbital carcinosarcoma were identified. Both tumors contained sarcomatous and carcinomatous components and invaded periorbital structures.
Conclusions
Carcinosarcoma may arise in the orbit or extend into the orbit from the paranasal sinuses. This malignant neoplasm should be aggressively treated with a combination of surgical resection, chemotherapy, and radiation therapy.
Financial Disclosure(s)
The authors have no proprietary or commercial interest in any materials discussed in this article.
Available online: June 17, 2008.
1Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia
2Department of Ophthalmology, Section of Ophthalmic Plastics and Orbital Surgery, Yale University School of Medicine, New Haven, Connecticut
3Department of Pathology, Maine Medical Center Pathology Division, Portland, Maine
4Department of Pathology, Emory University School of Medicine, Atlanta, Georgia
Correspondence: Hans E. Grossniklaus, MD, LF Montgomery Ophthalmic Pathology Laboratory, BT 428, 1365 Clifton Road, Atlanta, GA 30322
Manuscript no. 2008-191.
Financial Disclosure(s): The authors have no proprietary or commercial interest in any materials discussed in this article.
Supported in part by an unrestricted grant from Research to Prevent Blindness Inc, and National Institutes of Health P30 EY06360. Dr Grossniklaus is a recipient of the Research to Prevent Blindness Senior Scientific Investigator Award. The sponsor or funding organization had no role in the design or conduct of this research.
ABSTRACT