Idiopathic Intracranial Hypertension Is Associated with Lower Body Adiposity
Received 28 February 2009; received in revised form 20 May 2009; accepted 12 June 2009. published online 13 November 2009.
Objective
To characterize the obesity phenotype(s) in patients with idiopathic intracranial hypertension (IIH).
Design
Database study.
Participants
We studied 44 consecutive patients with IIH, in addition to 184 women attending the obesity clinic of the same medical center and 199 obese women participating in the first Israeli national survey on health and nutrition conducted in 1999 and 2000.
Methods
Anthropometric parameters were compared with those of 2 control groups of the same age range.
Main Outcome Measures
Weight, height, and waist and hip circumference were measured.
Results
Forty subjects, comprising 91.0% of this cohort, were either overweight (body mass index, 25.0–29.9 kg/m2) or obese (body mass index ≥ 30 kg/m2). Mean waist circumference was 95.3 cm for IIH, 99.8 cm for the national survey, and 114.5 cm for the obesity clinic cohort (P<0.001), whereas hip circumference was 121 cm for IIH, 118.4 cm for the national survey, and 125.8 cm (P = not significant) for the obesity clinic cohorts. Waist-to-hip ratio, a descriptive measure of body fat distribution approximately reflecting upper to lower body fat ratio, was 0.79 in the patients with IIH, 0.84 in the national survey group, and 0.91 in the obesity clinic cohort (P<0.001; all comparisons were adjusted for age and body mass index).
Conclusions
In IIH, fat tends to preferentially accumulate in the lower body relative to other obese women of the same range. Whereas most complications of obesity, such as hypertension, diabetes, dyslipidemia, and the metabolic syndrome, are linked to upper body adiposity, IIH may represent a unique condition potentially induced by nonvisceral fat-related mechanisms.
Financial Disclosure(s)
The authors have no proprietary or commercial interest in any materials discussed in this article.
Available online: November 12, 2009.
1Neuro-ophthalmology unit, Department of Ophthalmology, Tel Aviv-Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
2Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Correspondence: Anat Kesler, MD, Neuro-Ophthalmology Unit, Department of Ophthalmology, Tel Aviv-Sourasky Medical Center, Tel Aviv, Israel
Manuscript no. 2009-292.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
ABSTRACT