Ophthalmology
Volume 117, Issue 9 , Pages 1684-1691 , September 2010

Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: Analysis of the Retinal Nerve Fiber Layer Map for Glaucoma Detection

  • Christopher K.S. Leung, MD, MB ChB

      Affiliations

    • Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PRC
    • Corresponding Author InformationCorrespondence: Christopher Leung, MD, MB, ChB, Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PRC
    • ,
  • Shi Lam, MBBS

      Affiliations

    • Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PRC
    • ,
  • Robert N. Weinreb, MD

      Affiliations

    • Hamilton Glaucoma Center, University of California, San Diego, California
    • ,
  • Shu Liu, BM

      Affiliations

    • Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PRC
    • ,
  • Cong Ye, BM

      Affiliations

    • Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PRC
    • ,
  • Lan Liu, BM

      Affiliations

    • Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PRC
    • ,
  • Jing He, BM

      Affiliations

    • Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PRC
    • ,
  • Gilda W.K. Lai, BSc

      Affiliations

    • Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PRC
    • ,
  • Taiping Li, BM

      Affiliations

    • Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PRC
    • ,
  • Dennis S.C. Lam, MD, FRCOphth

      Affiliations

    • Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PRC

Received 15 June 2009 ,Revised 8 January 2010 ,Accepted 11 January 2010.

References 

  1. Budenz DL, Fredette MJ, Feuer WJ, Anderson DR. Reproducibility of peripapillary retinal nerve fiber thickness measurements with Stratus OCT in glaucomatous eyes. Ophthalmology. 2008;115:661–666
  2. Paunescu LA, Schuman JS, Price LL, et al. Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using StratusOCT. Invest Ophthalmol Vis Sci. 2004;45:1716–1724
  3. Leung CK, Cheung CY, Weinreb RN, et al. Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study. Ophthalmology. 2009;116:1257–1263
  4. Nassif N, Cense B, Park BH, et al. In vivo human retinal imaging by ultrahigh-speed spectral-domain optical coherence tomography. Opt Lett. 2004;29:480–482
  5. Hodapp E, Parrish RK, Anderson DR. Clinical Decisions in Glaucoma. In: St Louis: Mosby; 1993;p. 52–61
  6. Cirrus HD-OCT User Manual. Rev. A. Dublin, CA: Carl Zeiss Meditec Inc; 2008;4-18–9
  7. Quigley HA, Miller NR, George T. Clinical evaluation of nerve fiber layer atrophy as an indicator of glaucomatous optic nerve damage. Arch Ophthalmol. 1980;98:1564–1571
  8. Jonas JB, Dichtl A. Evaluation of the retinal nerve fiber layer. Surv Ophthalmol. 1996;40:369–378
  9. Wilson EB. Probable inference, the law of succession, and statistical inference. J Am Stat Assoc. 1927;22:209–212
  10. Hanley JA, McNeil BJ. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology. 1983;148:839–843
  11. Janes H, Pepe MS. Adjusting for covariates in studies of diagnostic, screening, or prognostic markers: an old concept in a new setting. Am J Epidemiol. 2008;168:89–97
  12. Budenz DL, Michael A, Chang RT, et al. Sensitivity and specificity of the Stratus OCT for perimetric glaucoma. Ophthalmology. 2005;112:3–9
  13. Sommer A, Katz J, Quigley HA, et al. Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. Arch Ophthalmol. 1991;109:77–83
  14. Medeiros FA, Zangwill LM, Bowd C, et al. Use of progressive glaucomatous optic disk change as the reference standard for evaluation of diagnostic tests in glaucoma. Am J Ophthalmol. 2005;139:1010–1018
  15. Budenz DL, Anderson DR, Varma R, et al. Determinants of normal retinal nerve fiber layer thickness measured by Stratus OCT. Ophthalmology. 2007;114:1046–1052
  16. Leung CK, Mohamed S, Leung KS, et al. Retinal nerve fiber layer measurements in myopia: an optical coherence tomography study. Invest Ophthalmol Vis Sci. 2006;47:5171–5176
  17. Hood DC, Harizman N, Kanadani FN, et al. Retinal nerve fibre thickness measured with optical coherence tomography accurately detects confirmed glaucomatous damage. Br J Ophthalmol. 2007;91:905–907

 Manuscript no. 2009-813.

 Financial Disclosure(s): Supported by The Chinese University of Hong Kong Direct Grant 08-09.

 The authors have made the following disclosures: Christopher K. S. Leung – Speaker honorarium – Carl Zeiss Meditec, Heidelberg Engineering, Topcon; Research support – Carl Zeiss Meditec, Optovue

 Robert N. Weinreb – Consultant – Optovue; Research support – Carl Zeiss Meditec, Heidelberg Engineering, Optovue

PII: S0161-6420(10)00053-9

doi: 10.1016/j.ophtha.2010.01.026

Ophthalmology
Volume 117, Issue 9 , Pages 1684-1691 , September 2010

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