Ophthalmology
Volume 117, Issue 9 , Pages 1700-1704, September 2010

Diurnal Intraocular Pressure Patterns are Not Repeatable in the Short Term in Healthy Individuals

  • Tony Realini, MD

      Affiliations

    • West Virginia University Eye Institute, Morgantown, West Virginia
    • Corresponding Author InformationCorrespondence: Tony Realini, MD, 1 Stadium Drive, P.O. Box 9193, Morgantown, WV 26505
    • ,
  • Robert N. Weinreb, MD

      Affiliations

    • Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California
    • ,
  • Stephen R. Wisniewski, PhD

      Affiliations

    • Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania

Received 18 September 2009; received in revised form 25 January 2010; accepted 26 January 2010. published online 16 June 2010.

Available online: June 16, 2010.

Purpose

To evaluate the short-term repeatability of diurnal intraocular pressure (IOP) patterns in eyes of subjects without glaucoma.

Design

Observational cohort study.

Participants

Forty healthy subjects without glaucoma.

Methods

Subjects underwent 12-hour diurnal IOP assessment sessions from 8:00 am to 8:00 pm on 2 visits 1 week apart. Intraocular pressure was assessed by Goldmann applanation tonometry. An analysis was performed to determine the agreement of individual diurnal IOP patterns from the first visit to the second visit. The intraclass correlation coefficient (ICC) was used to analyze both agreement of IOP values at each time point between visits and IOP change over periods between time points between visits.

Main Outcome Measures

Diurnal IOP patterns.

Results

Between-visit agreement of IOP values at each time point generally was fair to good, with ICCs ranging from 0.37 to 0.62 in right eyes and from 0.35 to 0.71 in left eyes. Between-visit agreement of IOP change over time between time points was uniformly poor and often below that expected by chance alone, with ICCs ranging from −0.25 to 0.15 in right eyes and from −0.40 to 0.22 in left eyes.

Conclusions

Eyes of healthy individuals do not manifest a sustained and reproducible diurnal IOP pattern when measured by Goldmann tonometry. A single-day assessment of IOP incompletely characterizes the diurnal IOP pattern.

Financial Disclosure(s)

The author(s) have no proprietary or commercial interest in any materials discussed in this article.

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 Manuscript no. 2009-1295.

 Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

 Supported by the National Eye Institute, Bethesda, Maryland (grant nos.: K23EY018859 and R03EY015682 [TR]); and by an unrestricted grant to West Virginia University from Research to Prevent Blindness, Inc., New York, New York.

PII: S0161-6420(10)00117-X

doi:10.1016/j.ophtha.2010.01.044

Ophthalmology
Volume 117, Issue 9 , Pages 1700-1704, September 2010

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