Ophthalmology
Volume 117, Issue 9 , Pages 1674-1683 , September 2010

Predicting the Onset of Glaucoma: The Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study

  • Robert N. Weinreb, MD

      Affiliations

    • Department of Ophthalmology, University of California-San Diego, Hamilton Glaucoma Center, La Jolla, California
    • Corresponding Author InformationCorrespondence: Robert N. Weinreb, MD, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0946
    • ,
  • Linda M. Zangwill, PhD

      Affiliations

    • Department of Ophthalmology, University of California-San Diego, Hamilton Glaucoma Center, La Jolla, California
    • ,
  • Sonia Jain, PhD

      Affiliations

    • Family and Preventive Medicine, University of California-San Diego, La Jolla, California
    • ,
  • Lida M. Becerra, MS

      Affiliations

    • Family and Preventive Medicine, University of California-San Diego, La Jolla, California
    • ,
  • Keri Dirkes, MPH

      Affiliations

    • Department of Ophthalmology, University of California-San Diego, Hamilton Glaucoma Center, La Jolla, California
    • ,
  • Jody R. Piltz-Seymour, MD

      Affiliations

    • University of Pennsylvania Health Systems, Bristol, Pennsylvania
    • ,
  • George A. Cioffi, MD

      Affiliations

    • Ophthal-Discoveries in Sight, Devers Eye Institute, Portland, Oregon
    • ,
  • Gary L. Trick, PhD

      Affiliations

    • Ophthalmology, Henry Ford Health System, Detroit, Michigan
    • ,
  • Anne L. Coleman, MD, PhD

      Affiliations

    • Jules Stein Institute-UCLA, Los Angeles, California
    • ,
  • James D. Brandt, MD

      Affiliations

    • University of California-Davis Eye Center, Sacramento, California
    • ,
  • Jefferey M. Liebmann, MD

      Affiliations

    • Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York
    • ,
  • Mae O. Gordon, PhD

      Affiliations

    • Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri
    • ,
  • Michael A. Kass, MD

      Affiliations

    • Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri
    • ,
  • OHTS CSLO Ancillary Study Group

Received 13 November 2009 ,Revised 15 March 2010 ,Accepted 17 March 2010.

References 

  1. Zangwill LM, Weinreb RN, Beiser JA, et al. Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study Group Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma. Arch Ophthalmol. 2005;123:1188–1197
  2. Alencar LM, Bowd C, Weinreb RN, et al. Comparison of HRT-3 glaucoma probability score and subjective stereophotograph assessment for prediction of progression in glaucoma. Invest Ophthalmol Vis Sci. 2008;49:1898–1906
  3. Gordon MO, Kass MA Ocular Hypertension Treatment Study Group. The Ocular Hypertension Treatment Study: design and baseline description of the participants. Arch Ophthalmol. 1999;117:573–583
  4. Zangwill LM, Weinreb RN, Berry CC, et al. OHTS CSLO Ancillary Study Group The Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study: study design and baseline factors. Am J Ophthalmol. 2004;137:219–227
  5. Zangwill LM, Weinreb RN, Berry CC, et al. Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study Racial differences in optic disc topography: baseline results from the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study. Arch Ophthalmol. 2004;122:22–28
  6. Wollstein G, Garway-Heath DF, Hitchings RA. Identification of early glaucoma cases with the scanning laser ophthalmoscope. Ophthalmology. 1998;105:1557–1563
  7. Swindale NM, Stjepanovic G, Chin A, Mikelberg FS. Automated analysis of normal and glaucomatous optic nerve head topography images. Invest Ophthalmol Vis Sci. 2000;41:1730–1742
  8. Tipping ME. Sparse Bayesian learning and the relevance vector machine. J Mach Learn Res. 2001;1:211–244
  9. Lee EW, Wei LJ, Amato DA. Cox-type regression analysis for large numbers of small groups of correlated failure time observations. In:  Klein JP,  Goel PK editor. Survival Analysis: State of the Art. Dordrecht, Netherlands: Kluwer; 1992;p. 237–247NATO ASI series, series E: Applied sciences. No. 211
  10. Ocular Hypertension Treatment Study Group, European Glaucoma Prevention Study Group. Validated prediction model for the development of primary open-angle glaucoma in individuals with ocular hypertension. Ophthalmology. 2007;114:10–19
  11. Harizman N, Zelefsky JR, Ilitchev E, et al. Detection of glaucoma using operator-dependent versus operator-independent classification in the Heidelberg retinal tomograph-III. Br J Ophthalmol. 2006;90:1390–1392
  12. Jaeschke R, Guyatt GH, Sackett DL Evidence-Based Medicine Working Group. Users' guides to the medical literature. III: How to use an article about a diagnostic test. B: what are the results and will they help me in caring for my patients?. JAMA. 1994;271:703–707
  13. Simel DL, Samsa GP, Matchar DB. Likelihood ratios with confidence: sample size estimation for diagnostic test studies. J Clin Epidemiol. 1991;44:763–770
  14. Harrell FE. Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression and Survival Analysis. In: New York: Springer; 2001;p. 493
  15. Ferreras A, Pajarin AB, Polo V, et al. Diagnostic ability of Heidelberg Retina Tomograph 3 classifications: glaucoma probability score versus Moorfields regression analysis. Ophthalmology. 2007;114:1981–1987
  16. Medeiros FA, Zangwill LM, Bowd C, et al. Agreement between stereophotographic and confocal scanning laser ophthalmoscopy measurements of cup/disc ratio: effect on a predictive model for glaucoma development. J Glaucoma. 2007;16:209–214
  17. Oddone F, Centofanti M, Rossetti L, et al. Exploring the Heidelberg Retinal Tomograph 3 diagnostic accuracy across disc sizes and glaucoma stages: a multicenter study. Ophthalmology. 2008;115:1358–1365
  18. Coops A, Henson DB, Kwartz AJ, Artes PH. Automated analysis of Heidelberg retinal tomograph optic disc images by glaucoma probability score. Invest Ophthalmol Vis Sci. 2006;47:5348–5355

 Manuscript no. 2009-1585.

 Financial Disclosure(s): The authors have made the following disclosures.

 R.N. Weinreb - Support - Heidelberg Engineering, GmbH.

 L.M. Zangwill - Support - Heidelberg Engineering, Heidelberg, Germany; Carl Zeiss Meditec Inc, Dublin, CA.

 J. Piltz - Support - Seymour, Pfizer, Inc., Alcon Laboratories, Inc., Allergan, Inc., Merck.

 G.A. Cioffi - Consultant - Allergan, Inc., Pfizer Inc, C.

 G.L. Trick - Consultant - Allergan, Inc.

 A.L. Coleman - Consultant - Alcon Laboratories, Inc., Allergan, Inc., Pfizer, Inc.

 J.D. Brandt - Consultant - Alcon Laboratories, Inc., Allergan, Inc., Pfizer, Inc.; Lecturer - Alcon Laboratories, Inc., Allergan, Inc., Pfizer, Inc.

 J.M. Liebmann - Consultant - Alcon Laboratories, Inc., Allergan, Inc., Optovue, Inc., Heidelberg Engineering, GmbH, Pfizer, Inc., Topcon Medical Systems, Inc., Diopsys, Inc.; Support - Carl Zeiss Meditec, Inc.; Diopsys, Inc., Heidelberg Engineering, GmbH, Optovue, Inc., Pfizer, Inc., Topcon Medical Systems, Inc.

 M.A. Kass – Consultant – Pfizer, Inc.

 Supported by NIH/NEI grants, EY11158 (RNW), (EY09341, EY09307 [MOG, MAK]), Horncrest Foundation awards, NIH Vision Core Grant P30 EY02687, Merck Research Laboratories, Pfizer Inc, White House Station, New Jersey.

PII: S0161-6420(10)00323-4

doi: 10.1016/j.ophtha.2010.03.044

Ophthalmology
Volume 117, Issue 9 , Pages 1674-1683 , September 2010

Article Tools

* Image Usage & Resolution