Ophthalmology
Volume 118, Issue 1 , Pages 66-70, January 2011

The Concave Iris in Pigment Dispersion Syndrome

  • Lance Liu, MBBS, FRANZCO

      Affiliations

    • Glaucoma Unit, Royal Victorian Eye and Ear Hospital, Victoria, Australia
    • Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    • Preston Eye Clinic, Preston, Victoria, Australia
    • Corresponding Author InformationCorrespondence: Lance Liu, MBBS, FRANZCO, Preston Eye Clinic, 268 Murray Road, Preston VIC 3072, Australia
    • ,
  • Ee Lin Ong

      Affiliations

    • Glaucoma Unit, Royal Victorian Eye and Ear Hospital, Victoria, Australia
    • Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    • ,
  • Jonathan Crowston, PhD, FRCOphth

      Affiliations

    • Glaucoma Unit, Royal Victorian Eye and Ear Hospital, Victoria, Australia
    • Preston Eye Clinic, Preston, Victoria, Australia

Received 9 November 2009; received in revised form 21 March 2010; accepted 30 April 2010. published online 31 August 2010.

Available online: August 30, 2010.

Objective

To visualize the changes of the iris contour in patients with pigment dispersion syndrome after blinking, accommodation, and pharmacologic miosis using anterior segment optical coherence tomography.

Design

Observational case series.

Participants

A total of 33 eyes of 20 patients with pigment dispersion syndrome.

Methods

Each eye was imaged along the horizontal 0- to 180-degree meridian using the Visante Anterior Segment Imaging System (Carl Zeiss Meditec, Dublin, CA). Scans were performed at baseline and after focusing on an internal fixation target for 5 minutes, forced blinking, accommodation, and pharmacologic miosis with pilocarpine 2%.

Main Outcome Measures

Quantitative analysis of the changes in the iris configuration.

Results

After 5 minutes of continual fixation, the iris became planar with the mean ± standard deviation curvature decreasing from 214±74 μm to 67±76 μm (P<0.05). The iris remained planar in all patients with pigment dispersion syndrome after forced blinking, but the iris concavity recovered to 227±113 μm (P = 0.34) and 238±119 μm (P = 0.19) with the −3.0 and −6.0 diopter lenses, respectively. Pilocarpine-induced miosis caused the iris to assume a planar configuration in all subjects.

Conclusions

This study shows that the iris in pigment dispersion syndrome assumes a planar configuration when fixating and that the concavity of the iris surface is not restored by blinking. Accommodation restored the iris concavity, suggesting that the posterior curvature of the iris in pigment dispersion syndrome is induced and probably maintained, at least in part, by accommodation.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found after the references.

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 Manuscript no. 2009-1562.

 Financial Disclosure(s): The author(s) have made the following disclosure(s): Dr Crowston is a consultant for the following: Pfizer, New York, New York; Alcon, Hünenberg, Switzerland; and Allergan, Irvine, CA; and Merck, Whitehouse Station, NJ.

PII: S0161-6420(10)00512-9

doi:10.1016/j.ophtha.2010.04.039

Ophthalmology
Volume 118, Issue 1 , Pages 66-70, January 2011

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