Ophthalmology
Volume 118, Issue 2 , Pages 402-407 , February 2011

Plaque Radiotherapy for Juxtapapillary Choroidal Melanoma: Tumor Control in 650 Consecutive Cases

Presented in part: at the Annual Meeting of the American Academy of Ophthalmology, Las Vegas, Nevada, 2006; the Gonin Club/Retina Society Meeting, Cape Town, South Africa, 2006; and the International Society of Ocular Oncology Meeting, Siena, Italy, 2007.

  • Mandeep S. Sagoo, MB, PhD

      Affiliations

    • Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania
    • Corresponding Author InformationCorrespondence: Mandeep S. Sagoo, MB, PhD, MRCOphth, FRCS(Ed.), UCL Institute of Ophthalmology, Moorfields Eye Hospital, 162 City Road, EC1V 2PD, UK
    • ,
  • Carol L. Shields, MD

      Affiliations

    • Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania
    • ,
  • Arman Mashayekhi, MD

      Affiliations

    • Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania
    • ,
  • Jorge Freire, MD

      Affiliations

    • Department of Radiation Oncology, Drexel University College of Medicine, Hahnemann Hospital, Philadelphia, Pennsylvania
    • ,
  • Jacqueline Emrich, PhD

      Affiliations

    • Department of Radiation Oncology, Drexel University College of Medicine, Hahnemann Hospital, Philadelphia, Pennsylvania
    • ,
  • Jay Reiff, PhD

      Affiliations

    • Department of Radiation Oncology, Drexel University College of Medicine, Hahnemann Hospital, Philadelphia, Pennsylvania
    • ,
  • Lydia Komarnicky, MD

      Affiliations

    • Department of Radiation Oncology, Drexel University College of Medicine, Hahnemann Hospital, Philadelphia, Pennsylvania
    • ,
  • Jerry A. Shields, MD

      Affiliations

    • Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania

Received 5 February 2010 ,Revised 28 May 2010 ,Accepted 7 June 2010.

References 

  1. Shields CL, Shields JA. Recent developments in the management of choroidal melanoma. Curr Opin Ophthalmol. 2004;15:244–251
  2. De Potter P, Shields CL, Shields JA, et al. Plaque radiotherapy for juxtapapillary choroidal melanoma: visual acuity and survival outcome. Arch Ophthalmol. 1996;114:1357–1365
  3. Lommatzsch PK, Lommatzsch R. Treatment of juxtapapillary melanomas. Br J Ophthalmol. 1991;75:715–717
  4. Gragoudas ES, Goitein M, Seddon J, et al. Preliminary results of proton beam irradiation of macular and paramacular melanomas. Br J Ophthalmol. 1984;68:479–485
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  8. Shields CL, Cater J, Shields JA, et al. Combined plaque radiotherapy and transpupillary thermotherapy for choroidal melanoma: tumor control and treatment complications in 270 consecutive patients. Arch Ophthalmol. 2002;120:933–940
  9. De Potter P, Shields CL, Shields JA, et al. Impact of enucleation versus plaque radiotherapy in the management of juxtapapillary choroidal melanoma on patient survival. Br J Ophthalmol. 1994;78:109–114
  10. Sagoo MS, Shields CL, Mashayekhi A, et al. Plaque radiotherapy for choroidal melanoma encircling the optic disc (circumpapillary choroidal melanoma). Arch Ophthalmol. 2007;125:1202–1209
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  17. Harbour JW, Murray TG, Byrne SF, et al. Intraoperative echographic localization of iodine 125 episcleral radioactive plaques for posterior uveal melanoma. Retina. 1996;16:129–134
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  19. Finger PT, Iezzi R, Esteveo ML, et al. Diode-light transillumination for ophthalmic plaque localization around juxtapapillary choroidal melanomas. Int J Radiat Oncol Biol Phys. 1999;44:887–890
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  21. Jampol LM, Moy CS, Murray TG, et al. COMS Follow-up of Plaqued Eyes Working Group (The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: IV. Local treatment failure and enucleation in the first 5 years after brachytherapy. COMS report no. 19). Ophthalmology. 2002;109:2197–2206
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  25. Gragoudas ES. Proton beam irradiation of uveal melanomas: the first 30 years (The Weisenfeld Lecture). Invest Ophthalmol Vis Sci. 2006;47:4666–4673
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  27. Collaborative Ocular Melanoma Study (COMS) Group. The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: V (Twelve-year mortality rates and prognostic factors: COMS report no. 28). Arch Ophthalmol. 2006;124:1684–1693
  28. Char DH, Quivey JM, Castro JR, et al. Helium ions versus iodine 125 brachytherapy in the management of uveal melanoma: a prospective, randomized, dynamically balanced trial. Ophthalmology. 1993;100:1547–1554
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 Manuscript no. 2010-197.

 Financial Disclosure(s): The authors have no proprietary or commercial interest in any of the materials discussed in this article.

 Support provided by a donation from Michael, Bruce, and Ellen Ratner, New York, NY (JAS, CLS), the Paul Kayser International Award of Merit in Retina Research, Houston TX (JAS), Mellon Charitable Giving from the Martha W. Rogers Charitable Trust, Philadelphia, PA (CLS), and the Eye Tumor Research Foundation, Philadelphia, Pennsylvania (CLS, JAS). MSS is supported by the Fulbright Fellowship in Cancer Research, the TFC Frost Trust, and Special Trustees of Moorfields Eye Hospital, London, UK.

PII: S0161-6420(10)00608-1

doi: 10.1016/j.ophtha.2010.06.007

Ophthalmology
Volume 118, Issue 2 , Pages 402-407 , February 2011

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